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Table 2 Fatigue scores at 6-month follow-up by APOE4 carrier status – negative binomial regression analysis

From: APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study

 

NOCOV (n = 48)

HOME (n = 33)

Hospitalised (ICU&WARD) (n = 75)

APOE ε4 –

APOE ε4 + 

OR (95% CI)

P value

APOE ε4 –

APOE ε4 + 

OR (95% CI)

P value

APOE ε4 –

APOE ε4 + 

OR (95% CI)

P value

n = 30

n = 18

n = 20

n = 13

n = 48

n = 27

Mean

Mean

Mean

Mean

Mean

Mean

Total Fatiguea

37.8

41.7

1.10 (0.93–1.31)

0.258

53.4

53.9

1.01 (0.78–1.31)

0.941

50.2

53.5

1.07 (0.91–1.25)

0.434

General Fatigueb

8.0

9.3

1.15 (0.93–1.43)

0.191

12.6

11.8

0.93 (0.73–1.20)

0.593

12.3

12.7

1.04 (0.87–1.24)

0.696

Physical Fatigueb

7.3

8.1

1.11 (0.90–1.37)

0.336

11.1

12.0

1.08 (0.81–1.42)

0.604

11.8

11.9

1.00 (0.83–1.20)

0.987

Mental Fatigueb

7.4

9.8

1.32 (1.08–1.63)

0.0062

11.2

10.8

0.96 (0.68–1.35) 0.821

8.0

9.9

1.23 (1.02–1.49)

0.029

Reduced Motivationb

6.8

6.1

0.90 (0.71–1.14)

0.389

8.2

8.1

0.99 (0.70–1.41) 0.96

8.5

8.3

0.98 (0.80–1.19) 0.845

Reduced Activityb

8.4

8.4

1.01 (0.79–1.28)

0.94

10.3

11.3

1.10 (0.81–1.50)

0.556

9.6

10.7

1.12 (0.93–1.34) 0.245

  1. Analysis of the effect of APOE4 status on mental fatigue was done by negative binomial regression. OR, odds ratio. Statistical significance at the level < 0.05 is shown in bold text.
  2. aPossible score from 20 (no fatigue) to 100 (highest possible fatigue);
  3. bPossible score from 4 (no fatigue) to 20 (highest possible fatigue)
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Acta Neuropathologica Communications

ISSN: 2051-5960

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