Table 1 Multivariate regression estimates and associated p-values for normalised S1P in the hippocampus
From: Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis
Variable | Coefficient (β) 1 | SE B 2 | 95% CI | p-value |
|---|---|---|---|---|
Braak Stage | 0.0392 | |||
Ctrl vs Braak I/II | -0.443 | 0.35 | -1.545, -0.090 | 0.0290 |
Ctrl vs Braak III/IV | -0.533 | 0.39 | -1.900, -0.283 | 0.0101 |
Ctrl vs Braak V/VI | -0.393 | 0.34 | -1.400, 0.002 | 0.0506 |
APOE Genotype | 0.0495 | |||
ϵ3/ϵ3 vs ϵ2/ϵ3 | 0.092 | 0.39 | -0.605, 1.013 | 0.6090 |
ϵ3/ϵ3 vs ϵ3/ϵ4 | -0.403 | 0.29 | -1.282, -0.074 | 0.0292 |
R 2 | 0.37 | |||
F | 3.12 | 0.025 |