Figure 2From: Distinct patterns of spread of prion infection in brains of mice expressing anchorless or anchored forms of prion protein Immunohistochemistry for PrPres in brains of tg44 mice following inoculation with different dilutions of RML scrapie. Panels a-e show PrPres staining (brown) using anti-PrP antibody D13. Mice shown in panels a-d had clinical signs consistent with prion infection, whereas mouse in panel e did not have clinical signs and was euthanized at the end of the experiment (668 dpi). The dilution of inoculum and day of euthanasia for each panel are as follows: a: 10-3, 371 dpi; b: 10-4, 382 dpi; c: 10-5, 480 dpi; d: 10-6, 528 dpi; e: 10-7, 668 dpi.Back to article page