PSP brain sections labeled with T22 and PHF13 display characteristic PSP hallmarks. PSP brain sections immunofluorescently labeled with T22 (red) and PHF13 (green). Intracellular tau oligomers detected with T22 partially colocalize with PHF13 (a-c). Oligomers resembling tufted astrocytes or extracellular deposits were also detected to partially colocalize with phosphorylated tau recognized by PHF13 (d-f). Characteristic globose-type NFTs were detected by T22 and PHF13 (g-i).