Figure 1

Topographic brain distribution of dipeptide repeat proteins (poly-GA) in patient #9 with Frontotemporal dementia associated with an expansion in C9ORF72. Regions shown are frontal cortex layer II (a), frontal cortex layer V (b), dentate gyrus (c) and area CA4 (d) of hippocampus, ventrolateral nucleus of thalamus (e), granule cells (f) and Purkinje cells (g) of cerebellum, dentate nucleus (h). Immunoperoxidase-haematoxylin ×40 microscope magnification.