Figure 6

Macroscopical and histological data in a 24.5 WG foetus (LIS_TUB_053_foetus21) with polymicrogyria-like cortical dysplasia and TUBA1A mutation. Fronto-parietal polymicrogyria with short and vertically oriented sylvian fissure and cerebellar hypoplasia (a), on coronal sections, enlarged germinal zone with polymicrogyria involving the frontal, perisylvian and temporal areas (arrow) (b), malrotated and hypoplastic hippocampus (c), scattered nodular heterotopias in the deep white matter (d), roughly shaped dentate nuclei (e), absent olivary nuclei with bilateral, large olivary heterotopias found in the dorsal part of the medulla (white arrows) (f) (Scale bars: b, 2 mm, c, d: 100 μm, e: 1 mm, f: 200 μm).