Figure 1From: Mutations in tubulin genes are frequent causes of various foetal malformations of cortical development including microlissencephaly Schematic representation of the functional domains of TUBA1A, TUBB2B and TUBB3 tubulin subunits and distribution of mutations associated with foetal cases with malformations of cortical development. Illustrated domains are the N-terminal that contains the guanine nucleotide-binding region, intermediate domain, and C-terminal domains that constitutes the binding surface for MAPs and molecular motors such as kinesins and dyneins. In β-tubulin, they correspond to residues 1–229, 230–371, and 372–450, [36] and in α-tubulin, to residues 1–205, 206–381, 382–451 [37], respectively. Mutations associated with a lissencephaly (classical and with cerebellar hypoplasia) phenotype are indicated in red, with microlissencephaly in green, with polymicrogyria-like cortical dysplasia in pink. For recurrent variations the number of occurrences is indicated in brackets.Back to article page