Factor | HR (95% CI) (p value to exclude from model) | |||
---|---|---|---|---|
Model 1* (all pts) | Model 2* (all pts) | Model 3* (all pts) | Model 4* (all pts) | |
Fixed variables | Â | Â | Â | Â |
Age (years) | 1.01 (0.99, 1.02) | 1.01 (1.00, 1.02) | 1.01 (1.00, 1.02) | 1.00 (0.98, 1.02) |
 Tumour grade |  |  |  |  |
  III | 1 | 1 | 1 | 1 |
  IV | 1.84 (1.10, 3.08) | 2.25 (1.33, 3.83) | 2.43 (1.48, 3.98) | 1.53 (0.81, 2.92) |
 WHO Performance status |  |  |  |  |
  0 | 1 | 1 | 1 | 1 |
  1 | 0.86 (0.58, 1.27) | 0.93 (0.63, 1.39) | 0.93 (0.63, 1.38) | 0.79 (0.51, 1.21) |
  2 | 1.42 (0.93, 2.17) | 1.63 (1.06, 2.53) | 1.62 (1.05, 2.50) | 1.39 (0.87, 2.22) |
  3 | 1.23 (0.69, 2.20) | 1.54 (0.85, 2.81) | 1.46 (0.93, 2.97) | 1.64 (0.88, 3.06) |
 Gender |  |  |  |  |
  Male | 1 | 1 | 1 | 1 |
  Female | 0.80 (0.59, 1.07) | 0.82 (0.61, 1.10) | 0.80 (0.57, 1.03) | 0.91 (0.66, 1.25) |
 Additional independent factors |  |  |  |  |
 IDH1 |  |  |  |  |
 Normal | 1 | 1 |  | 1 |
 Mutated | 0.45 (0.29, 0.67) (p < 0.001) | 0.58 (0.37, 0.91) (p = 0.015) |  | 0.32 (0.18, 0.56) (P < 0.001) |
 PTEN |  |  |  |  |
 Normal |  |  | 1 |  |
 Hemizygous deletion |  |  | 1.83 (1.29, 2.61) |  |
 Homozygous deletion |  |  | 1.47 (0.68, 3.16) P = 0.003 |  |
 MGMT methylation |  |  |  |  |
 <10% |  | 1 | 1 | 1 |
 ≥10% |  | 0.59 (0.42, 0.82) P = 0.002 | 0.49 (0.36, 0.67) (p < 0.001) | 0.44 (0.30, 0.63) (p = 0.002) |