TY - JOUR AU - Collins, Vincent Peter AU - Ichimura, Koichi AU - Di, Ying AU - Pearson, Danita AU - Chan, Ray AU - Thompson, Lindsay C. AU - Gabe, Rhian AU - Brada, Michael AU - Stenning, Sally P. PY - 2014 DA - 2014/06/20 TI - Prognostic and predictive markers in recurrent high grade glioma; results from the BR12 randomised trial JO - Acta Neuropathologica Communications SP - 68 VL - 2 IS - 1 AB - We evaluated the prognostic and predictive value of a range of molecular changes in the setting of a randomised trial comparing standard PCV (procarbazine, CCNU (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea) and vincristine) chemotherapy with the standard temozolomide (TMZ) 5-day (200 mg/m2/day) schedule and a 21-day (100 mg/m2/day) schedule in chemo-naïve, high-grade glioma (non-oligodendroglial tumours; WHO (World Health Organisation) grades III and IV) patients at first progression following radiotherapy. SN - 2051-5960 UR - https://doi.org/10.1186/2051-5960-2-68 DO - 10.1186/2051-5960-2-68 ID - Collins2014 ER -