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Figure 3 | Acta Neuropathologica Communications

Figure 3

From: CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis

Figure 3

Mutant SOD1 -induced vacuolation is ameliorated by steroid treatment. WT tissue shows staining of large motor neurons (black arrows) in the cranial motor nuclei (A, E, I) and spinal cord (M), with no structural abnormalities. In contrast, SOD1 G93A saline (B, F, J, N) and SOD1 G93A free MP (C, G, K, O) show a reduction in large motor neurons, with more morphologically abnormal neurons (white arrows). There is also substantial vacuolation. SOD1 G93A mice treated with 2B3-201 (D, H, L, P) have reduced vacuolation in the cranial motor nuclei (Q-S). Scale bar applies to all images. Images shown are representative median values in the graphs. * p<0.05; ** p<0.01; *** p<0.001.

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