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Figure 1 | Acta Neuropathologica Communications

Figure 1

From: CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis

Figure 1

Disease progression assessed by weight and motor behaviour. Weight data (unadjusted – A; normalized at 60 days – B) shows a gradual increase in weight in all groups, with no significant difference between genotypes or treatment groups at any time point. Rotarod scores (C) were higher at all time points for WT compared with all SOD1 G93A treatment groups, and all SOD1 G93A groups showed a typical decline over time, with no significant difference between any of the treatment groups. There was no significant difference between groups for weight data with area-under-the-curve analysis (D); SOD1 G93A 2B3-201 had significantly greater area under the curve (increased motor scores) compared with free MP, but there was no difference when compared with SOD1 G93A saline. Data are presented as mean ± standard error. *** p<0.001.

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