NFT load does not correlate with the differences in Arc expression between rTg4510 and control mice. Surface area occupied by tangles (presented as means ± s.e.m. on log10 scale for clarity) in the forebrain regions with significant Arc expression (presented in Figure 3) in rTg4510 mice plotted versus mean (±s.e.m.) log Arc::dVenus expression difference between control and rTg4510 mice. Spearman R = 0.13, P = 0.75. N = 4 control littermates, 4 transgenic mice.