Figure 7

Deficits in Novel Object Recognition and Location task. In the novel object recognition test (NOR) the object discrimination ratio was defined as the difference in exploration time for the novel object (in sec) divided by the total exploration time (in sec). a, c) McGill APP transgenic rats exhibited lower recognition memory indices than wild type littermates at a) pre-plaque (3 months) and c) post-plaque (13 months) stages. In the novel object location test (NOL) (b, d) the object discrimination ratio was defined as the difference in exploration time for the displaced object (sec) divided by the total exploration time (in sec). Data is expressed as mean ± SEM and analyzed with One-Way ANOVA, followed by Tukey’s post hoc test; *P < 0.05, **P < 0.01, ***P < 0.001.