Characterization of McSA1 and pab27576 immunoreactivities by super-resolution microscopy. To further characterize the distribution of McSA1 and pab27576 signals, pyramidal neurons from lamina III and lamina V of the parietal cortex were imaged by SIM in 3-month old amyloid-plaque free transgenic rats. Note the distinct intracellular localization of McSA1 immunoreactivity (green) with that of pab27576 (red), denoting Aβ-amyloid peptides and APP/CTFs, respectively. DAPI (gray) indicates the boundaries of the neuronal nucleus. From left to right are frontal and oblique views, followed by higher magnification images of 3D-reconstructions.