Figure 6From: Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma TET1 and TET3 expression are increased in DIPG tumors relative to normal brain. mRNA expression profiling of H3F3A mutant DIPG tumor tissue shows relative increased expression of TET1 and TET3, but not TET2, in tumor relative to adjacent non-neoplastic brain control.Back to article page