Table 4 Number and types of IDH 1/2 mutations detected by IHC, Sanger sequencing and PCR (n = 133)
From: A new sensitive PCR assay for one-step detection of 12 IDH1/2 mutations in glioma
IDH1/2 WT | IDH1 mutated | IDH2 mutated | % Mutated cases | |||||
|---|---|---|---|---|---|---|---|---|
R132H | R132C | R132 Other | R100 | R172K | R172 Other | |||
IHC | 72 | 61 | NA | NA | NA | NA | NA | 46 |
Sanger sequencing | 66 | 58 | 2 | 6* | 0 | 1 | 0 | 50 |
IDH1/2 PCR | 61 | 60 | 3 | 7 | 0 | 1 | 1 | 54 |