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Table 4 Number and types of IDH 1/2 mutations detected by IHC, Sanger sequencing and PCR (n = 133)

From: A new sensitive PCR assay for one-step detection of 12 IDH1/2 mutations in glioma

  IDH1/2 WT IDH1 mutated IDH2 mutated % Mutated cases
   R132H R132C R132 Other R100 R172K R172 Other  
IHC 72 61 NA NA NA NA NA 46
Sanger sequencing 66 58 2 6* 0 1 0 50
IDH1/2 PCR 61 60 3 7 0 1 1 54
  1. IHC: Immunohistochemistry; PCR: Polymerase chain reaction; WT: Wild-type; NA: not applicable.
  2. *3 R132S; 2 R132G; 1 R132L.