Figure 2

Structure of WT and G93A hSOD1 in the critical C4F6 binding site. (a) The critical amino acids thought to be involved in C4F6 binding are located in a loop structure formed by amino acids 90–93. (b) Alignment of structures of G93A hSOD1from 3 different crystals with 16 subunits in the PDB database. (c) Merged alignment of WT and G93A hSOD1. (d) View of aligned complete structures for WT and G93A hSOD1.