Quantitative immunolabelling of cells from different tissue areas. Quantitative cellular immunolabelling in different tissue areas from sections of brain and spinal cord tissue from multiple sclerosis (MS; 42 sections from 17 cases with 175 areas examined within the plaque (P), 175 within the peri-plaque (PP), 145 within the white matter (WM) and 195 within the grey matter (GM)), non-neurological controls (C; 14 sections from 7 cases with 70 areas examined from both WM and GM) and neurological controls (NC; 11 sections from 9 cases with 55 areas examined from both WM and GM). Groups show mean values +/_ standard error. Significant results are shown by p value examining differences between the MS group and controls or neurological controls for both WM and GM; differences between the control groups were not included for reasons of clarity. Within the MS group, differences were analysed between P and PP/PP and WM.