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Figure 3 | Acta Neuropathologica Communications

Figure 3

From: The instability of the BTB-KELCH protein Gigaxonin causes Giant Axonal Neuropathy and constitutes a new penetrant and specific diagnostic test

Figure 3

Nonsense mediated mRNA decay in some GAN patients. Gigaxonin mRNA levels of four control individuals (c1-4, in black), all GAN patients (in red) and their relatives (in grey) are measured using quantitative RT-PCR with GAN-exons9-11 (A) and GAN-exons4-5 (B), and normalized using HPRT mRNA levels. Each mRNA level is expressed as the fold change to the mean value of the four control mRNAs. (B), (F) and (M) (S1 or S2) stand for non-affected Brother, Father, Mother, and sister, respectively N = 3 experiments. (T-test, *, p < 0,05; **, p < 0,01, ***, p < 0,001; error bars represent standard deviation SD. A 2-fold change is statistically different).

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