Representative pS6 expression in Type II FCD. Examples of pS6 expression in samples of severe (a) and less severe (b, arrows) Type II FCD; in both cases, the immunoreactivity suggests the presence of mTOR pathway hyperactivation in DNs. c-e. Details of the regions marked with asterisks in a, b. Scale bars: 268 μm (a,b); 60 μm (c,d,e) .