Tau accumulation in the nucleus accumbens in tangle-predominant dementia

Table 2 Demography and basic clinical and neuropathological features of TPD cases

	Case 1	Case 2	Case 3	Case 4	Case 5	Case 6	Case 7
Age at death	89	102	90	85	89	78	86
Sex	F	F	F	F	F	M	F
Dementia	+	+	+	+	MCI	MCI	+
Psychiatric symptoms
Delusion	+	+	+	+	+	+	-
Anxiety	+	-	-	-	-	-	-
Depression	-	-	-	+	-	-	-
Brain weight (g)	940	970	1170	1300	1230	1220	1130
Atrophy	mi(Fr)	mi(Fr/T)	-	-	-	-	-
Plaque stage (1)	0	0	A*	0	0	0	0
NFT stage (1)	III	III	III	III	IV	III	III
Argyrophilic grain stage (2)	0	0	0	0	II	II	0
Hippocampal sclerosis	-	-	+	-	-	-	-
Vascular lesions	+	-	-	+	-	-	-
α-synuclein (hip/T**)	+§	-	-	-	-	-	-
TDP-43 (hip/T**)	-	-	-	-	-	-	-
Acb tau score	3	2	2	3	3	2	3

F, Female; M, Male; MCI, Mild cognitive impairment; mi, Mild; Fr, Frontal; T, Temporal; Acb, The nucleus accumbens. *A small number of diffuse Aβ deposits were seen in the temporal cortex. The Acb tau score was determined according to the method described in the text. (1) The senile plaque and NFT staging were based on the description by Braak and Braak [6]. (2) The argyrophilic grain staging was based on the description by Saito et al. [29]. **Immunohistochemistry for α-synuclein and TDP-43 was performed in tissue sections of the hippocampus, parahippocampal gyrus and adjacent temporal neocortex. § α-Synuclein pathology in this case was mild, corresponding to stage 1 by the 3^rd report of the DLB consortium [22].

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