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Table 2 Demography and basic clinical and neuropathological features of TPD cases

From: Tau accumulation in the nucleus accumbens in tangle-predominant dementia

  Case 1 Case 2 Case 3 Case 4 Case 5 Case 6 Case 7
Age at death 89 102 90 85 89 78 86
Sex F F F F F M F
Dementia + + + + MCI MCI +
Psychiatric symptoms        
    Delusion + + + + + + -
    Anxiety + - - - - - -
    Depression - - - + - - -
Brain weight (g) 940 970 1170 1300 1230 1220 1130
Atrophy mi(Fr) mi(Fr/T) - - - - -
Plaque stage (1) 0 0 A* 0 0 0 0
NFT stage (1) III III III III IV III III
Argyrophilic grain stage (2) 0 0 0 0 II II 0
Hippocampal sclerosis - - + - - - -
Vascular lesions + - - + - - -
α-synuclein (hip/T**) - - - - - -
TDP-43 (hip/T**) - - - - - - -
Acb tau score 3 2 2 3 3 2 3
  1. F, Female; M, Male; MCI, Mild cognitive impairment; mi, Mild; Fr, Frontal; T, Temporal; Acb, The nucleus accumbens. *A small number of diffuse Aβ deposits were seen in the temporal cortex. The Acb tau score was determined according to the method described in the text. (1) The senile plaque and NFT staging were based on the description by Braak and Braak [6]. (2) The argyrophilic grain staging was based on the description by Saito et al. [29]. **Immunohistochemistry for α-synuclein and TDP-43 was performed in tissue sections of the hippocampus, parahippocampal gyrus and adjacent temporal neocortex. § α-Synuclein pathology in this case was mild, corresponding to stage 1 by the 3rd report of the DLB consortium [22].