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Figure 3 | Acta Neuropathologica Communications

Figure 3

From: NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma

Figure 3

Expression of NOTCH ligands across MB molecular subgroups and MYC/JAG2 expression correlation in MB primary tumors, in histological MB subtypes, and in distinct metastatic MB stages. Dot plots showing relative expression (log2) of JAG1 (a), JAG2 (b), DLL1 (c), and DLL3 (d), across MB subgroups in a representative dataset of 103 human MB tumors[25]: SHH, n = 33; WNT, n = 8; Grp3 (Group 3), n = 27; Grp4 (Group 4), n = 35. (e) Correlation between MYC and JAG2 mRNA expression (log2) in a representative dataset of 103 human MB tumors[25]. r: Pearson’s value; p: p values. (f) Correlation study of JAG2 and MYC levels in Group 3 MB cases[25]. Box plots showing JAG2 (g) and MYC (h) expression (log 2) according to the following MB histological variants[26]: classic (n = 51), desmoplastic (desmop.) (n = 6), and (LCA) large cells/anaplastic (n = 17); center line = median. Box plots showing JAG2 (i) and MYC (j) expression (log 2) in MB tumors clustered according to metastatic stage[23]: M0, n = 42; M1, n = 7; ≥M2, n = 9; center line = median.

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