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Figure 5 | Acta Neuropathologica Communications

Figure 5

From: Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain

Figure 5

Effect of MOG-IgG on neurons. A. (Left) NeuN immunoreactivity at 2w. Area lacking neurons outlined red. (Right) % NeuN loss (NeuN immunonegative area/ipsilatral hemispheric area). B. Node of Ranvier: ankG, ankyrin G; Caspr, contactin associated protein; MBP, myelin basic protein; MOG, myelin oligodendrocyte glycoprotein; Nav, voltage-gated Na+ channel; Nfil, neurofilament. C. MBP immunoreactivity. (Top) Normal and abnormal white matter tracts. (Bottom) % abnormal tracts in injected hemisphere. D. Caspr immunoreactivity within white matter tracts. (Top) Hemispheres injected with IgGCON + Chu and IgGMOG + Chu. (Bottom) Data summary. E. AnkG immunoreactivity within white matter tracts. (Top) Hemispheres injected with IgGCON + Chu and IgGMOG + Chu. (Bottom) Data summary. F. Nfil immunoreactivity. (Top) Hemispheres injected with IgGCON + Chu and IgGMOG + Chu. Arrowheads: white matter tracts. (Bottom) Data summary (a.u. arbitrary units). 5 mice per group. P <0.05*, <0.01**. Bar 0.5 mm (A), 20 μm (C), 10 μm (D, E), 50 μm (F).

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