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Figure 1 | Acta Neuropathologica Communications

Figure 1

From: Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins

Figure 1

Schematic representation of TDP-43 domains containing epitopes recognized by the MABs reported here. The TDP-43 domains harboring the epitopes recognized by 45 newly generated MAbs were mapped to regions along the entire length of TDP-43 (A-F) by immunoblot and indirect peptide ELISA and the putative amino acid stretches included in these epitopes is depicted in the table to the right of the schematic. RRM: RNA-recognition motif; NLS: bipartite nuclear localization signal; NES: nuclear export signal.

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