Distinct origins of dura mater graft-associated Creutzfeldt-Jakob disease: past and future problems

Table 2 Molecular classification of dCJD and sCJD

Classification^a	Codon 129 genotype	PrP^Sctype	Transmission type^b	Original PrP^Sc	Existing PrP^Sc
np-dCJD	M/M	1	M1	M1	M1
p-dCJD	M/M	i ^c	V2	V2 ^d	Mi
sCJD-MM1	M/M	1	M1	M1	M1
sCJD-VV2	V/V	2	V2	V2	V2
sCJD-MV2K	M/V	i + 2	V2	V2	Mi + V2
sCJD-MV2K+C	M/V	i + 2	V2	M2C^e + V2	M2C + Mi + V2

^aAccording to Parchi, 1999 [17]; and Parchi, 2011 [18].
^bAccording to Bishop, 2010 [24]; Kobayashi, 2007 [20]; and Kobayashi, 2013 [23].
^cIntermediate type located between types 1 and 2 PrP^Sc.
^dAlthough not only V2 PrP^Sc but also Mi PrP^Sc can cause p-dCJD if transmitted to the 129 M/M individuals, the primary origin of Mi PrP^Sc is V2 PrP^Sc (see text).
^eM2 PrP^Sc can be divided into two subgroups based on histopathological phenotypes. M2C PrP^Sc causes a predominant cortical pathology, whereas M2T PrP^Sc causes atrophy of thalamic and inferior olivery nuclei.

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