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Table 2 Molecular classification of dCJD and sCJD

From: Distinct origins of dura mater graft-associated Creutzfeldt-Jakob disease: past and future problems

Classificationa Codon 129 genotype PrPSctype Transmission typeb Original PrPSc Existing PrPSc
np-dCJD M/M 1 M1 M1 M1
p-dCJD M/M i c V2 V2 d Mi
sCJD-MM1 M/M 1 M1 M1 M1
sCJD-VV2 V/V 2 V2 V2 V2
sCJD-MV2K M/V i + 2 V2 V2 Mi + V2
sCJD-MV2K+C M/V i + 2 V2 M2Ce + V2 M2C + Mi + V2
  1. aAccording to Parchi, 1999 [17]; and Parchi, 2011 [18].
  2. bAccording to Bishop, 2010 [24]; Kobayashi, 2007 [20]; and Kobayashi, 2013 [23].
  3. cIntermediate type located between types 1 and 2 PrPSc.
  4. dAlthough not only V2 PrPSc but also Mi PrPSc can cause p-dCJD if transmitted to the 129 M/M individuals, the primary origin of Mi PrPSc is V2 PrPSc (see text).
  5. eM2 PrPSc can be divided into two subgroups based on histopathological phenotypes. M2C PrPSc causes a predominant cortical pathology, whereas M2T PrPSc causes atrophy of thalamic and inferior olivery nuclei.