Figure 2
From: Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres
Arsenic trioxide induces apoptosis in glioblastoma neurosphere cells. A) Western blots show induction of caspase-3 cleavage in HSR-GBM1, 040622 and 040821 cells following treatment with 2.5 μM or 5 μM ATO. B) Cell cycle analysis by flow cytometry performed on neurosphere lines after ATO treatment reveal a significant increase in the sub-G1 population in all 3 neurosphere lines at 2.5 μM and 5 μM ATO. In 040821, there is also a significant increase in the sub-G1 population at 1 μM ATO.