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Figure 7 | Acta Neuropathologica Communications

Figure 7

From: In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques

Figure 7

Model for the relationship between plaque density kinetics and amyloid plaque growth in vivo. The term ccritical refers to the minimum critical concentration of Aβ that is necessary to form plaque seeds (a prerequisite discovered by in vitro studies). This initial step of plaque formation was observed by recording the plaque density kinetics in vivo. According to the plaque density kinetics and applying the aforementioned requirement different relations of the Aβ concentrations comparative to the critical minimum concentration can be assigned to the different growth phases.

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