Figure 4

Bifid analysis of the plaque growth data of long-term imaging. (a) Mean volume over time (error bars, 95% CI). A sigmoid function was fitted to the mean volume (black line). The dotted line indicates the inflection point of the fitted curve dividing the cubic and asymptotic parts of the function. (b) Kinetics of plaque radii. According to the cubic and asymptotic phase of volume growth two linear regressions (black lines) were fit from 12 to 23.3 and 23.5 to 27.5 months of age. This analysis was done for each single plaque. (c) Comparison of the plaque growth rates resulting from the bifid analysis with the values gained from the young and old imaging cohort. Black lines with error bars show medians with interquartile range. Multiple comparisons were performed by Kruskal-Wallis test with Dunn’s Post-hoc test. ***P < 0.001