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Table 2 Agreement of biomarker measures for NI and subtle cognitive changes

From: Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition

 

aHV

SPARE-AD

HCI

PC-FDG-PET

T-tau

P-tau181

  

(+)

(−)

(+)

(−)

(+)

(−)

(+)

(−)

(+)

(−)

aHV

 

66.0%

34.0%

56.4%

43.6%

66.1%

33.9%

60.4%

39.6%

55.75%

44.25%

SPARE-AD

0.06

 

68.5%

31.5%

50.7%

49.3%

79.0%

21.0%

45.3%

54.7%

HCI

0.05

0.05

 

64.5%

45.5%

63.6%

36.4%

46.0%

54.0%

PC-FDG-PET

0.33

0.03

0.10

 

50.8%

49.2%

51.0%

49.0%

T-tau

0.06

0.04

0.11

0.07

 

63.6%

36.4%

P-tau 181

0.15

0.0

−0.01

−0.05

0.31

 
  1. Numbers below the diagonal represent Cohen’s kappa index. Numbers above the diagonal represent the percentage of subjects that were classified the same way by the pair of NI biomarkers (+) and the percentage of cases that were classified differently by the pair of NI biomarkers (−).