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Table 1 Increased biometal concentrations in the brain of preclinical CLN6 Merino sheep

From: Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

   Zna Cua
  Age Control CLN6 Control CLN6
Frontal 3 11.1 ± 0.2 11.1 ± 0.7 2.0 ± 0.2 2.3 ± 0.2*
7 11.4 ± 0.2 12.1 ± 1.4 2.2 ± 0.3 2.7 ± 0.6
Occipital 3 11.2 ± 0.4 11.2 ± 1.2 2.2 ± 0.5 2.8 ± 0.3*
7 13.1 ± 0.5 13.9 ± 1.9 2.5 ± 0.2 3.4 ± 0.9*
Parietal 3 10.7 ± 0.9 11.0 ± 0.4 1.8 ± 0.3 2.5 ± 0.1^
7 12.9 ± 0.6 13.6 ± 0.4* 2.5 ± 0.4 2.1 ± 0.3
Thalamus 3 10.7 ± 1.3 10.5 ± 0.6 2.1 ± 0.4 1.8 ± 0.1
7 10.6 ± 1.0 11.6 ± 1.3 2.7 ± 1.2 2.7 ± 1.3
Cerebellum 3 12.2 ± 1.1 12.5 ± 1.3 2.8 ± 0.4 3.0 ± 0.5
7 11.4 ± 0.5 11.6 ± 0.5 3.4 ± 0.5 2.3 ± 0.4^
Brainstem 3 11.2 ± 1.0 11.7 ± 0.6 2.5 ± 0.3 2.8 ± 0.3*
7 8.52 ± 0.8 9.2 ± 0.4 1.9 ± 0.2 1.5 ± 0.4
Liver 3 53.9 ± 18.5 36.3 ± 9.2* 20.2 ± 2.6 37.1 ± 1.6#
7 28.1 ± 5.3 29.5 ± 3.0 40.4 ± 7.7 58.2 ± 6.5#
Muscle 3 22.0 ± 4.5 21.5 ± 1.9 0.6 ± 0.4 0.5 ± 0.2
7 19.9 ± 3.0 27.3 ± 4.1^ 0.2 ± 0.1 0.3 ± 0.2
Plasma 3 11.7 ± 1.1 12.0 ± 2.1 13.6 ± 2.0 14.3 ± 2.7
7 14.0 ± 1.4 10.5 ± 1.8* 12.8 ± 1.1 10.2 ± 2.2
  1. aMetal concentrations in the CNS and peripheral tissues of 3 and 7 month old control and CLN6 Merino sheep were measured using ICP-MS. The concentrations of Zn and Cu in each tissue are expressed as mean ± S.D. Values correspond to μg metal/g tissue. *p < 0.05, ^p < 0.01, # p < 0.001 by Student’s t test.