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Table 1 Increased biometal concentrations in the brain of preclinical CLN6 Merino sheep

From: Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

  

Zna

Cua

 

Age

Control

CLN6

Control

CLN6

Frontal

3

11.1 ± 0.2

11.1 ± 0.7

2.0 ± 0.2

2.3 ± 0.2*

7

11.4 ± 0.2

12.1 ± 1.4

2.2 ± 0.3

2.7 ± 0.6

Occipital

3

11.2 ± 0.4

11.2 ± 1.2

2.2 ± 0.5

2.8 ± 0.3*

7

13.1 ± 0.5

13.9 ± 1.9

2.5 ± 0.2

3.4 ± 0.9*

Parietal

3

10.7 ± 0.9

11.0 ± 0.4

1.8 ± 0.3

2.5 ± 0.1^

7

12.9 ± 0.6

13.6 ± 0.4*

2.5 ± 0.4

2.1 ± 0.3

Thalamus

3

10.7 ± 1.3

10.5 ± 0.6

2.1 ± 0.4

1.8 ± 0.1

7

10.6 ± 1.0

11.6 ± 1.3

2.7 ± 1.2

2.7 ± 1.3

Cerebellum

3

12.2 ± 1.1

12.5 ± 1.3

2.8 ± 0.4

3.0 ± 0.5

7

11.4 ± 0.5

11.6 ± 0.5

3.4 ± 0.5

2.3 ± 0.4^

Brainstem

3

11.2 ± 1.0

11.7 ± 0.6

2.5 ± 0.3

2.8 ± 0.3*

7

8.52 ± 0.8

9.2 ± 0.4

1.9 ± 0.2

1.5 ± 0.4

Liver

3

53.9 ± 18.5

36.3 ± 9.2*

20.2 ± 2.6

37.1 ± 1.6#

7

28.1 ± 5.3

29.5 ± 3.0

40.4 ± 7.7

58.2 ± 6.5#

Muscle

3

22.0 ± 4.5

21.5 ± 1.9

0.6 ± 0.4

0.5 ± 0.2

7

19.9 ± 3.0

27.3 ± 4.1^

0.2 ± 0.1

0.3 ± 0.2

Plasma

3

11.7 ± 1.1

12.0 ± 2.1

13.6 ± 2.0

14.3 ± 2.7

7

14.0 ± 1.4

10.5 ± 1.8*

12.8 ± 1.1

10.2 ± 2.2

  1. aMetal concentrations in the CNS and peripheral tissues of 3 and 7 month old control and CLN6 Merino sheep were measured using ICP-MS. The concentrations of Zn and Cu in each tissue are expressed as mean ± S.D. Values correspond to μg metal/g tissue. *p < 0.05, ^p < 0.01, # p < 0.001 by Student’s t test.
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Acta Neuropathologica Communications

ISSN: 2051-5960

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