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Table 2 Differentiating pathological and biochemical features between PSP and CTE

From: Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer

Pathological features PSP CTE
Tau protein isoform profile -4-repeat predominant tau -Both 4- and 3-repeat tau
   -4-repeat predominant astrocytic tangles in subpial and periventricular regions
Characteristic features -Neuronal (NFTs, neuropil threads) and glial pathology (tufted astrocytes, coiled bodies) in a typical distribution -Perivascular NFTs locate at depths of sulci and in superficial cortical layers
  -Neuronal loss in STN and dentate nucleus -Subpial, perivascular and periventricular astrocytic tangles
   -Relatively mild Aβ pathology
   -Ghost tangles in limbic region and temporal neocortex
Shared features -Associated TDP-43 related pathology limited to limbic region -TDP-43 pathology in CTE tends to be more widespread involving cortical region in stage III and IV
  -Neuronal loss in SN and LC -Neuronal loss in SN and LC
Distribution of hyperphosphorylated tau pathology -SN, STN, GP, pons -Cortical regions including frontal cortex, medial temporal lobe, thalamus and brainstem
  -Striatum, oculomotor complex, medulla, dentate nucleus, inferior olive and neocortex  
  1. CTE: chronic traumatic encephalopathy, GP: globus pallidus, LC: locus ceruleus, NFT: neurofibrillary tangle, PSP: progressive supranuclear palsy, SN: substantia nigra, STN: subthalamic nucleus.