From: Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
Pathological features | PSP | CTE |
---|---|---|
Tau protein isoform profile | -4-repeat predominant tau | -Both 4- and 3-repeat tau |
 |  | -4-repeat predominant astrocytic tangles in subpial and periventricular regions |
Characteristic features | -Neuronal (NFTs, neuropil threads) and glial pathology (tufted astrocytes, coiled bodies) in a typical distribution | -Perivascular NFTs locate at depths of sulci and in superficial cortical layers |
 | -Neuronal loss in STN and dentate nucleus | -Subpial, perivascular and periventricular astrocytic tangles |
 |  | -Relatively mild Aβ pathology |
 |  | -Ghost tangles in limbic region and temporal neocortex |
Shared features | -Associated TDP-43 related pathology limited to limbic region | -TDP-43 pathology in CTE tends to be more widespread involving cortical region in stage III and IV |
 | -Neuronal loss in SN and LC | -Neuronal loss in SN and LC |
Distribution of hyperphosphorylated tau pathology | -SN, STN, GP, pons | -Cortical regions including frontal cortex, medial temporal lobe, thalamus and brainstem |
 | -Striatum, oculomotor complex, medulla, dentate nucleus, inferior olive and neocortex |  |