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Table 1 Distribution of immunoreactive inclusions positive to AT8 and TDP antibodies

From: Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer

  Tau-immunoreactive lesions TDP-43-immunoreative lesions
Neuritic plaques NFTs & PreTs Coiled bodies Neuropil threads Tufted astrocytes Perivascular astrocytic tangles Subpial astrocytic tangles NCIs NIIs Threads
Anterior frontal + ++ ++ ++ + + ++ - - -
Parietal + + ++ ++ + + + - - -
Temporal cortex + + + ++ + - ++ - - -
Hippocampus - +++ + +++ - - + + + +
Amygdala - +++ - +++ - + NA - - +
Caudate - + + +++ ++ + NA - - -
Putamen - + + + + - NA - - -
Globus pallidus - + ++ + - - NA - - -
Internal capsule - NA ++ +++ - - NA - - -
STN - ++ ++ +++ - - NA    
Substantia nigra - ++ ++ +++ - - NA - - -
Red nucleus - ++ +++ +++ - - NA - - -
Oculomotor nucleus - ++ - +++ - - NA - - -
Pons-tegmentum - ++ +++ +++ - - NA    
Pons-base - ++ + +++ - - -    
Locus ceruleus - +++ + +++ - - NA    
Medullary tegmentum - ++ +++ +++ - - + + - +
Inferior olive - ++ + ++ - - -    
Dentate nucleus - ++ - ++ - - NA    
Cerebellar wm - ++ NA ++ - - -    
  1. (-) none; (+) sparse; (++) moderate; (+++) frequent, NA-not applicable; blank spaces indicate that immunohistochemistry staining was not performed in the corresponding region; 3R: 3-repeat tau isoform; 4R: 4-repeat tau isoform: Aβ: amyloid beta; AT8: phosphorylated tau; NCIs: neuronal cytoplasmic inclusions; NFTs: neurofibrillary tangles, NIIs: neuronal intranuclear inclusions; preTs: pretangles; STN: subthalamic nuclei; wm: white matter.