Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer

Table 1 Distribution of immunoreactive inclusions positive to AT8 and TDP antibodies

	Tau-immunoreactive lesions							TDP-43-immunoreative lesions
	Neuritic plaques	NFTs & PreTs	Coiled bodies	Neuropil threads	Tufted astrocytes	Perivascular astrocytic tangles	Subpial astrocytic tangles	NCIs	NIIs	Threads
Anterior frontal	+	++	++	++	+	+	++	-	-	-
Parietal	+	+	++	++	+	+	+	-	-	-
Temporal cortex	+	+	+	++	+	-	++	-	-	-
Hippocampus	-	+++	+	+++	-	-	+	+	+	+
Amygdala	-	+++	-	+++	-	+	NA	-	-	+
Caudate	-	+	+	+++	++	+	NA	-	-	-
Putamen	-	+	+	+	+	-	NA	-	-	-
Globus pallidus	-	+	++	+	-	-	NA	-	-	-
Internal capsule	-	NA	++	+++	-	-	NA	-	-	-
STN	-	++	++	+++	-	-	NA
Substantia nigra	-	++	++	+++	-	-	NA	-	-	-
Red nucleus	-	++	+++	+++	-	-	NA	-	-	-
Oculomotor nucleus	-	++	-	+++	-	-	NA	-	-	-
Pons-tegmentum	-	++	+++	+++	-	-	NA
Pons-base	-	++	+	+++	-	-	-
Locus ceruleus	-	+++	+	+++	-	-	NA
Medullary tegmentum	-	++	+++	+++	-	-	+	+	-	+
Inferior olive	-	++	+	++	-	-	-
Dentate nucleus	-	++	-	++	-	-	NA
Cerebellar wm	-	++	NA	++	-	-	-

(-) none; (+) sparse; (++) moderate; (+++) frequent, NA-not applicable; blank spaces indicate that immunohistochemistry staining was not performed in the corresponding region; 3R: 3-repeat tau isoform; 4R: 4-repeat tau isoform: Aβ: amyloid beta; AT8: phosphorylated tau; NCIs: neuronal cytoplasmic inclusions; NFTs: neurofibrillary tangles, NIIs: neuronal intranuclear inclusions; preTs: pretangles; STN: subthalamic nuclei; wm: white matter.

ISSN: 2051-5960