Illustrations of chronic traumatic encephalopathy (CTE) pathology. Tau immunohistochemistry demonstrates subpial astrocytic tangles in the depth of sulci of the frontal cortex (A), perivascular astrocytic tangles in the insula (B) and parietal cortices (C) and neurofibrillary tangles (NFTs) are occasionally observed in the perivascular region (white arrow, B). There is marked neuronal loss with ghost tangles (arrowhead) and NFTs (arrow) in the CA1 hippocampal subregion on H&E (D) and amyloid-β deposition on the ghost tangles can be observed (inset in D). TDP-43 immunohistochemistry shows occasional neuronal cytoplasmic inclusions (NCIs) in the dentate fascia of the hippocampus (E), a neuronal intranuclear inclusion (NII) in the entorhinal cortex (F), and, occasional NCIs and threads in the CA1 hippocampal subregion (G). Extensive tau-immunoreactive NFTs and neuropil threads (NTs) are observed in CA1 (H) and throughout the hippocampal formation and these NFTs and NTs are stained positive using either 3-repeat (I) and 4-repeat tau antibodies (J). A, B, C, H: tau immunohistochemistry (AT8), D: H&E, Inset in D: Aβ immunohistochemistry, E-G: TDP-43 immunohistochemistry, I: 3-repeat, and J: 4-repeat tau immunohistochemistry. Bar in J = 50 μm in A, H-J, = 100 μm in B and = 25 μm in D-G.