Figure 4

Intragenic amplifications in paediatric high grade glioma. (a) Copy number breakpoint within KIDINS200 on chromosome 2p25.1, flanking the MYCN amplicon in a case of pHGG. (b) Recurrent copy number breakpoint within KCND2 on chromosome 7q31.31 in two cases of pHGG, in both cases part of the MET amplicon, though targeting either the 5′ or 3′ end of the gene. Dark green: confirmed region of gain; Light green: region within which breakpoint lies, as defined by the resolution of probes on the array.