Expression of total tau in the hippocampus. High magnification micrographs of one NDE (A; #6) and one AD (B; #34) case stained with an antibody towards non-phosphorylated tau (tau-13). (A) Tau-13 immunoreactivity in the NDE case was strong in the neuropil and weak in the soma, except in NFT-containing neurons (arrowhead). However, granular immunoreactivity or GVD staining was not observed with the tau-13 antibody. The AD case (B) contained overall more intense staining in the somatodendritic compartment (arrowheads), but tau-13 immunoreactivity was not enriched in GVDs. Scale bar: 25 μm.