Posterior fossa and spinal gangliogliomas form two distinct clinicopathologic and molecular subgroups

Table 1 Clinical and radiological data for two morphological groups of ganglioglioma

	Pathology group	Age @ diagNosis (years)	Gender	Dominant site of tumor	*BRAF*: p.V600E	*BRAF* duplication	*KIAA1549-BRAF fusion gene*	Neuroimaging
								Midline location	Circumscribed	Cysts/necrosis	Hemorrhage	Enhancement	Edema	Restricted diffusion
GG01	I	6	M	Cerebellar hemisphere	Yes	No	No	No	No	0	0	+	+	No
GG02	I	9	F	Cerebellum	Yes	No	No	n/a
GG03	I	21	F	Cerebellar hemisphere	Yes	No	No	No	Yes	0	0	++	+++	Yes
GG04	I	9	F	Medulla	Yes	No	n/a	No	No	0	0	+++	0	No
GG05	I	8	F	Medulla	Yes	No	n/a	No	Yes	0	0	++	0	n/a
GG06	I	8	M	Medulla	Yes	No	n/a	No	No	0	0	+++	+	Yes
GG07	I	15	F	MCP	Yes	No	No	No	No	0	0	+++	++	No
GG08	I	8	F	Cerebellar hemisphere	No	No	No	No	No	+++	0	+	0	No
GG09	I	11	F	MCP	No	No	n/a	No	Yes	0	0	++++	0	n/a
GG10	I	11	F	Medulla	No	No	n/a	No	No	0	0	++	++	n/a
GG11	I	12	M	Medulla	No	No	No	No	No	0	0	+++	++	Yes
GG12	I	1.8	M	Pons	No	No	No	No	No	0	0	+	++	No
GG13	I	21	M	MCP	No	No	No	No	No	+	0	+++	+	n/a
GG14	I	0.6	M	MCP	No	No	No	No	No	0	0	+	+	No
GG15	I	15	F	Cervico-medullary	No	No	No	n/a
GG16	I	14	M	Medulla	No	No	No	No	No	0	0	++++	++	No
GG17	II	12	M	Vermis	No	Yes	Yes - ex16:ex9	No	Yes	++	0	+	0	Yes
GG18	II	4	F	Vermis	No	Yes	Yes - ex15:ex9	Yes	Yes	+	+	+++	+	Yes
GG19	II	12	F	Cord (thoraco-lumbar)	No	Yes	Yes - ex15:ex9	Yes	No	+	+	++	0	n/a
GG20	II	16	F	Cord (cervico-thoracic)	No	Yes	Yes - ex15:ex9	Yes	Yes	+++	0	++	+++	n/a
GG21	II	18	M	Cord (cervico-thoracic)	No	Yes	Yes - ex15:ex9	Yes	No	+++	+	+	++++	n/a
GG22	II	9	F	Vermis	No	Yes	Yes - ex15:ex9	No	Yes	++	0	+++	++	No
GG23	II	17	F	Vermis	No	Yes	Yes - ex16:ex9	No	Yes	++	+	+	++	Yes
GG24	II	10	M	Cord (cervical)	No	Yes	Yes - ex16:ex11	Yes	Yes	+++	+	++	++	n/a
GG25	II	9	M	Vermis	No	Yes	Yes - ex16:ex11	Yes	No	++++	0	++++	+	Yes
GG26	II	4	M	Medulla	No	No	No	No	No	0	0	+++	++	Yes
GG27	II	9	M	Midbrain	No	No	No	No	Yes	+++	0	+	++	n/a

ISSN: 2051-5960