Spatiotemporal progression of the Tau pathology through neural networks. LVs encoding hTau46WT were bilaterally injected into the CA1 layer of rat brains (n = 5). Eight months later, the animals were sacrificed, and the whole brain was processed for immunohistochemical analysis to show AT8-related pTau. The brains were virtually separated into five sections: (a) bregma +5.20 to +1.40, (b) bregma +1.20 to -1.40, (c) bregma -1.80 to -4.30, (d) bregma -4.52 to -6.04 and (e) bregma -6.30 to -7.80. The bar scale is indicated on the figure. These data showed that phospho-hTau46WT is found all over the brain eight months post-LVs delivery.