Progressive loss of large neurons and reciprocal increase in small neurons with skein-like/rounded inclusions. Skein-like/rounded inclusions more often appear in the small-sized neurons than granular/dot-like deposits, especially in OAH and total areas (a-d). This relative prevalence was increased up to 68.8% in OAH (b) upon relative increase of small neurons in OAH (f, 76.9%) and DL (e, 55.6%) at the advanced stage. A shift in size was absent in ON (g). The relative prevalence of small neurons in total areas was increased up to 65.4% and that of large neurons decreased to 0% at advanced phase (h). Significant p values of differences in prevalence are depicted.