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Table 3 Variants detected within the non-coding region of mtDNA in normal brain tissue (n = 13)

From: The identification of mitochondrial DNA variants in glioblastoma multiforme

    Percentage change in variant (%)  
Reference position Reference Variant 03-965 04-273 05-470 07-104 07-445 07-635 08-012 08-026 09-005 09-152 16-1 22-1 20-1 Gene region
16069 C T    7.2            D loop - Membrane attachment site, Hypervariable segment 1
16126 T C    5.2            D loop - Membrane attachment site, Hypervariable segment 1, 7S DNA
16145 G A    4.8            D loop - Membrane attachment site, Hypervariable segment 1, 7S DNA, termination-associated sequence
16179 C T          4.3      D loop - Membrane attachment site, Hypervariable segment 1, 7S DNA
16222 C T    5.1            
16261 C T    9.4            
16293 A G   16.1             
16356 T C          3.0      
16519 T C 57.5   54.5    56.0   57.6 58.3 59.4     D loop - Membrane attachment site, 7S DNA
9 G T    5.8            
10 T C    5.8            
66 G T              3.2 D-loop - Hypervariable segment 2, membrane attachment site, 7S DNA
73 A G    6.2           
150 C T          4.4      D loop - Hypervariable segment 2, H-strand origin, Membrane attachment site, 7S DNA
189 A G        3.0       
195 T C          4.5      D loop - Hypervariable segment 2, H-strand origin, Membrane attachment site
242 C T    7.7            D loop - Hypervariable segment 2, H-strand origin, mtTF1 binding site, Membrane attachment site
751 A T        3.9        12s ribosomal RNA (rRNA)
2232 A T       3.0         16s ribosomal RNA (rRNA)
2647 G C    12.1            
3010 G A    3.5            
  1. Variants represented those that were present at or above the 3% mutation threshold selection criteria. Variants that have not been previously reported are in bold.