Figure 2

Topography of FUS inclusions in aFTLD-U and late-onset BIBD. The density of FUS inclusions throughout the brain and spinal cord were graded on a 3 point scale and then color coded as green (0, absent), green-yellow (0.5+, rare), yellow (1+, mild), orange (2+, moderate) and red (3+, severe). Pathology grades were used to generate topographical maps for (A-C) aFTLD-U and (D-E) BIBD cases. Brain regions are labeled as follows: 1 frontal cortex, 2 orbitofrontal cortex, 3 primary motor cortex, 4 primary sensory cortex, 5 superior and middle temporal cortex, 6, parietal cortex, 7 occipital cortex, 8 cingulate gyrus, 9 midbrain, 10 pons, 11, medulla, 12 spinal cord, 13 dentate nucleus, 14 amygdala, 15 entorhinal cortex, 16 anterior striatum, 17 globus pallidus, 18 posterior striatum, 19 thalamus, 20 subthalamic nucleus, 21 substantia nigra, 22 hippocampus, 23 dorsal medulla, 24 inferior olive, 25 cerebellum.