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Table 1 Characteristics of the NMO and MS tissues used

From: T cell-activation in neuromyelitis optica lesions plays a role in their formation

Disease Activity Region
NMO 1-1 LA Cerebellum, medulla oblongata
NMO 1-2 EA Spinal cord
NMO 1-3 LA Spinal cord
NMO 1-4 EA Spinal cord
NMO 1-5 LA Mesencephalon
NMO 1-6A LA Periventricular (4th ventricle)
NMO 1-10A LA Temporal lobe
NMO 2-49 Acute, EA Optic nerve
NMO 3-2 Chronic, IA Spinal cord
NMO 4-49 Subacute/chronic LA-IA Spinal cord
NMO 5-2 EA, LA Medulla oblongata
NMO 6-2 LA Spinal cord
NMO 6-4 IA Medulla oblongata
AMS 1-1A EA, LA, IA Spinal cord
AMS 1-10D EA, LA, IA Temporal lobe
SPMS 1-12 SEL, IA Optic nerve
SPMS 1-10 SEL IA Medulla
SPMS 2-19 SEL IA Spinal cord
SPMS 2-20 SEL, IA Spinal cord
SPMS 2-21A SEL, IA Spinal cord
AMS 6-15 IA Spinal cord
SPMS 3-31 SEL, IA Medulla oblongata
AMS 2-6 EA Brain
RRMS 1 EA, LA Brain
AMS 3-5 EA, LA Brain
AMS 4-2 EA, LA Brain
AMS 5-97 EA, LA Brain
  1. Active lesions were identified and staged based on their dense infiltration by macrophages/activated microglia, and, in the case of NMO, by the presence of large numbers of neutrophilic granulocytes. Macrophages contained either early myelin degradation products (i.e. they were MOG+; early active lesions (EA)) or late myelin degradation products (i.e. they were PLP+; late active lesions (LA)). Inactive lesions (IA) had sharp lesion borders without macrophage infiltration of microglia activation, and slowly expanding lesions (SEL) were classified according to their inactive center, surrounded by a rim of activated microglia with some macrophages with myelin degradation products at the lesion margin.