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Table 1 Characteristics of the NMO and MS tissues used

From: T cell-activation in neuromyelitis optica lesions plays a role in their formation

Disease

Activity

Region

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NMO 1-1

LA

Cerebellum, medulla oblongata

NMO 1-2

EA

Spinal cord

NMO 1-3

LA

Spinal cord

NMO 1-4

EA

Spinal cord

NMO 1-5

LA

Mesencephalon

NMO 1-6A

LA

Periventricular (4th ventricle)

NMO 1-10A

LA

Temporal lobe

NMO 2-49

Acute, EA

Optic nerve

NMO 3-2

Chronic, IA

Spinal cord

NMO 4-49

Subacute/chronic LA-IA

Spinal cord

NMO 5-2

EA, LA

Medulla oblongata

NMO 6-2

LA

Spinal cord

NMO 6-4

IA

Medulla oblongata

AMS 1-1A

EA, LA, IA

Spinal cord

AMS 1-10D

EA, LA, IA

Temporal lobe

SPMS 1-12

SEL, IA

Optic nerve

SPMS 1-10

SEL IA

Medulla

SPMS 2-19

SEL IA

Spinal cord

SPMS 2-20

SEL, IA

Spinal cord

SPMS 2-21A

SEL, IA

Spinal cord

AMS 6-15

IA

Spinal cord

SPMS 3-31

SEL, IA

Medulla oblongata

AMS 2-6

EA

Brain

RRMS 1

EA, LA

Brain

AMS 3-5

EA, LA

Brain

AMS 4-2

EA, LA

Brain

AMS 5-97

EA, LA

Brain

  1. Active lesions were identified and staged based on their dense infiltration by macrophages/activated microglia, and, in the case of NMO, by the presence of large numbers of neutrophilic granulocytes. Macrophages contained either early myelin degradation products (i.e. they were MOG+; early active lesions (EA)) or late myelin degradation products (i.e. they were PLP+; late active lesions (LA)). Inactive lesions (IA) had sharp lesion borders without macrophage infiltration of microglia activation, and slowly expanding lesions (SEL) were classified according to their inactive center, surrounded by a rim of activated microglia with some macrophages with myelin degradation products at the lesion margin.