Figure 6
From: T cell-activation in neuromyelitis optica lesions plays a role in their formation
Entry of human immunglobulins to lesions provoked by different CNS antigen-specific T cells in NMO-IgG seropositive animals. (A-F) T cells specific for MBP (A,B), S100β (C,D) and MOG (E,F) were used to induce CNS inflammation, followed by transfer of NMO-IgG 4 days after T cell transfer. The animals were sacrificed 5 days after T cell transfer. For histological evaluation, their spinal cords were reacted with anti-human IgG (brown reaction product) and counterstained with hematoxylin to reveal nuclei (blue). Overviews (A,C,E) and details (B,D,F) of representative spinal cord sections are shown. Bars = 100 μm.