Figure 9

Immunogold labeling TEM/negatively stain of cerebrospinal fluid from AD brains and age matched controls. a) A higher density of dityrosine (labeled with 15 nm) and Aβ (labeled with 5 nm) labeling was observed for CSF from an AD patient (top images) compared to b) age matched control. In CSF of AD patients, we can identify two different areas of labeling, low-density co-localization (☐), and high density co-localization (◯) of dityrosine and Aβ. We observe significant labeling levels for AD CSF compared to virtually no labeling in CSF from control patients. Inserts show magnified images for further clarity.