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Table 1 Details of heavy metal staining in LC and motor neurons of MND patients and controls

From: Heavy metals in locus ceruleus and motor neurons in motor neuron disease

Group Diagnosis Age Gender LC no. Pos LC no. Neg LC% Pos LC% Pos Category SMN AMG grade 12n AMG grade NAm AMG grade 3n/4n AMG grade
MND SALS 71 Female 0 68 0 Low - - - 4n-
  SALS 62 Female 1 72 1 Low - - - 4n+
  SALS 66 Female 2 90 2 Low + + - 4n-
  SALS 38 Male 4 81 5 High - - - NA
  SALS 77 Female 4 72 5 High + - - 4n+
  SALS 81 Female 5 52 9 High ++ ++ ++ 3n+
  SALS 59 Female 14 82 15 High - - - 4n-
  SALS 46 Male 12 60 17 High ++ + + 4n+
  SALS 67 Female 17 66 20 High ++ ++ ++ 4n-
  SALS 45 Male 13 46 22 High - - ++ 4n-
  SALS C9orf72 74 Male 15 48 24 High - - - 4n-
  SALS 60 Female 32 79 29 High + + - 3n-
  SALS 49 Male 27 57 32 High + + ++ NA
  SPMA C9orf72 60 Female 0 60 0 Low + + - 4n-
  SPMA 58 Male 11 97 10 High ++ - - 4n+
  SPMA 84 Male 21 64 25 High + - - 3n-
  SPMA 74 Male 23 48 32 High ++ - + 4n+
  SPMA 53 Male 56 14 80 High + + - 4n-
  FMND 70 Male 21 75 22 High - - - 4n-
  FMND C9orf72 59 Male 2 32 6 High + - + 4n-
  FMND C9orf72 76 Female 5 79 6 High + + - 4n-
  FMND SOD1 41 Male 0 50 0 Low ++ - - 4n-
  FMND SOD1 47 Female 4 90 4 High ++ + ++ 4n-
  FMND Kennedy 53 Male 2 101 2 Low - - - 4n-
Control Normal 86 Female 0 35 0 Low + + + NA
  Normal 55 Female 0 38 0 Low - - - NA
  Normal 77 Male 0 42 0 Low - NA NA NA
  Normal 24 Male 0 122 0 Low - NA NA NA
  Normal 82 Female 0 66 0 Low NA NA NA NA
  Normal 77 Female 0 29 0 Low NA NA NA NA
  Normal 44 Male 0 90 0 Low NA NA NA NA
  Normal 30 Female 0 82 0 Low NA NA NA NA
  Normal 75 Female 0 45 0 Low NA NA NA NA
  Normal 71 Male 1 74 1 Low NA NA NA NA
  Normal 47 Female 1 57 2 Low NA NA NA NA
  Normal 77 Female 2 98 2 Low NA NA NA NA
  Normal 55 Male 3 99 3 Low NA NA NA NA
  Normal 26 Male 3 54 5 High + + - NA
  Normal 52 Female 6 75 7 High NA NA NA NA
  Normal 54 Male 12 65 16 High NA NA NA NA
  Normal 74 Male 9 35 20 High - - - 4n+
  Alcohol 36 Male 0 58 0 Low NA NA NA NA
  Alcohol 49 Female 0 70 0 Low NA NA NA NA
  Alcohol 33 Male 20 57 26 High NA NA NA NA
  Multiple sclerosis 51 Female 17 69 20 High NA NA NA NA
  Parkinson dis. 83 Male 0 13 0 Low + NA NA 3n++
  Parkinson dis. 72 Female 0 12 0 Low NA NA NA 4n+
  Parkinson dis. 74 Male 0 11 0 Low NA NA NA 4n-
  1. 3n: Oculomotor neurons, 4n: Trochlear neurons, 12n: Hypoglossal neurons, NA: Not available, NAm: Nucleus ambiguus neurons, SMN: Spinal motor neurons (see text for other abbreviations).