Pathology\ Brain regions | PrPScdepositiona | Vacuolationb | Reactive astrocytosisc |
---|---|---|---|
Frontal | Layers 5, 6 ++/+++ (S/PL/FG) | Layer 6 +++ | Pattern1: layer 1 + |
Layers 2–5 ++ | Pattern 2: layers 1–4 ++ | ||
Layers 1–4 + (FG) |  | Pattern 3: layers 1–6 +++ | |
Parietal | Layers 5, 6 ++ | Layers 5–6 ++ | Pattern1: layer 6 ++ |
(S/PL/FG) | Layers 2–4 + | Pattern 2: layers 2–6 ++ | |
Layers 1–4 + (FG) | |||
Temporal | Layers 5, 6 ++/+++ (FG) | Lattern 1: | Pattern 1: layers 1–5 ++++ |
Layers 1–4 ++ (FG) | Layers 3–6 +++ | Pattern 2: layers 1–5 +/++ | |
Layer 2 SS | |||
Pattern 2: | |||
Layers 5–6 +++ | |||
Layers 2–4 ++++ (SS) | |||
Occipital | Layers 5, 6 + (FG) | Layer 6 + | Layers 1–6 −/+ |
Layers 1–4 −/+ (FG) | |||
Cingulate | Layers 1–6 +++ (FG) | Layers 2–3 ++ | Layers 2–6 ++++ |
Layers 4–5 +++ | |||
Layer 6 ++ | |||
Insula | Layers 5, 6 +++ (FG) | Layers 5–6 +++ | Layers 1–4 +++ |
Layers 1–4 ++ (FG) | Layers 2–3 ++ | Layers 5, 6 − | |
Caudate | +++ (S, FG) | +++ | +++ |
Putamen | +++ (S, FG) | +++ | +++ |
Globus pallidus | Ext. +++ (FG) | Ext. + | Ext.++/+++ |
Int. ++/+++ (FG) | Int. + | Int. ++ | |
Thalamusd | Rostral: med.+/++ (S), lat. − | Rostral: med.++, lat.−/+ | Rostral: med.++/+++, lat. +/++ |
Middle: med. + (S), lat. − | Middle: med.++, lat.+ | Middle & caudal: med. ++/+++, lat. −/+ | |
Caudal: med. 1+ but focal 2+, lat. - | Caudal: med.++/+++, lat. + | ||
Amygdala | ++/+++ (FG) | +++ | ++/+++ |
Hippocampusd | Dentate gyrus, CA4, CA3, and CA2: −/+ | CA4, CA3, CA2, and CA1 prox. – | CA4, CA3 ++ |
CA2, CA1 prox. – | |||
CA1: prox. ++, CA1 dist.+++ (FG) | CA1 dis. ++ | CA1 dis. ++, | |
Subiculucm: +++ | Subiculum: | Subiculum ++, | |
Entorhinal cortex: layers 5, 6 ++/+++ | Layer 4 +++ | Entorhinal cortex: layers 2–6 ++ | |
Layer 2 +/++ | |||
Layers 1–4 −/++ (FG) | Entorhinal cortex | Transentorhinal cortex: layers 2–6 +++ | |
Transentorhinal cortex: layers 1–6 +++ (FG) | : layers 2,4 +++ | ||
Transentorhinal cortex | |||
 | : layers 2–6 +++ | ||
Cerebellum | Molecular and granular layers −/+ | Molecular and granular Layers – dentate nucleus + | Molecular layer ++/+++ |
Granular layer +/++ | |||
Dentate nucleus + | |||
Dentate nucleus + | |||
Midbrain | Periaqueductal gray and tegmentum + (FG) | Periaqueductal gray ++ | Periaqueductal gray + |
Tegmentum + | Tegmentum ++/+++ | ||
Substantia nigra | ++/+++ (FG) | ++ | +/++ |
Medulla | Tegmentum ++ (FG) | Tegmentum + | Tegmentum + |
Inf. olive ++/+++ (FG) | Inf. olive - | Inf. olive + |