Figure 1From: Genetic CJD with a novel E200G mutation in the prion protein gene and comparison with E200K mutation cases Family pedigree. Family pedigree of the proband of British descent with E200G mutation. Circles indicate females, and squares indicate males. Those whose gender is not disclosed are indicated with rhombi. A diagonal bar in the symbols indicate deceased. Arabic numerals “3” and “5” indicate the numbers of individuals. The proband with the E200G mutation (E200G+) is indicated by closed circle and arrowhead and her sibling with the same E200 mutation is also marked by “E200G+” (+EtOH = alcoholism, d. = died at age, lung ca = lung cancer, CHF = congestive heart failure, h/o RPD = history of rapidly progressive dementia).Back to article page