Family pedigree. Family pedigree of the proband of British descent with E200G mutation. Circles indicate females, and squares indicate males. Those whose gender is not disclosed are indicated with rhombi. A diagonal bar in the symbols indicate deceased. Arabic numerals “3” and “5” indicate the numbers of individuals. The proband with the E200G mutation (E200G+) is indicated by closed circle and arrowhead and her sibling with the same E200 mutation is also marked by “E200G+” (+EtOH = alcoholism, d. = died at age, lung ca = lung cancer, CHF = congestive heart failure, h/o RPD = history of rapidly progressive dementia).