Patterns of PrP deposits in brains with PRNP D178N and E200K mutations. A-C, there are small dot like inclusions in the white matter of a case with D178N mutation (A, B, ICSM35 and KG9), no cerebellar threads (C). D-F, E200K mutation with sparse threads in the subcortical white matter (D, ICSM35 and E, KG9) and the cerebellar white matter (F). The inset in (D) shows a rare straight PrP positive filament and the arrowhead points at a short stub or dot of abnormal PrP. The cerebellar white matter (F) of the same case shows occasional thicker, straight filaments of abnormal PrP (arrowheads). Scale bar corresponds to 140 μm in (D), to 80 μm in B, E and to 40 μm in all other panels.