Time-course of Aβ aggregation in brains of APP
mice. Brains from 5, 6, 7, and 8 months old animals (n = 5-8) were analyzed by histological staining with an anti-Aβ (4G8) antibody. Representative pictures of Aβ deposition in these mice are shown for the cortical (a) and hippocampal areas (b). The burden of amyloid deposits was measured in cortex (c) and hippocampus (d). The values were expressed as means ± SEM of the different animals used in each group. The scale bar corresponds to 250 μm.