Brain reperfusion, or glucose administration decreased IgG entrapment in hypoperfused brain capillaries. Immunofluorescence analysis examining endogenous IgG entrapment in brain capillaries shows that brain reperfusion, or glucose administration decreases IgG entrapment in the brain capillaries of the cortex (A), and similarly decreases IgG entrapment in the brain capillaries of the hippocampus (B). Data are means ± SEM (n = 3 animal per group, 3 sections per animal’s brain). 1 VO, one vessel occlusion for 24 hours; S, saline; R, brain reperfusion; G, glucose administration. **P < 0.01 / ****P < 0.0001 compared with contralateral saline (One-way analysis of variance (ANOVA) followed by Tukey’s multiple comparisons test).