TY - JOUR AU - ElAli, Ayman AU - Thériault, Peter AU - Préfontaine, Paul AU - Rivest, Serge PY - 2013 DA - 2013/11/13 TI - Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation JO - Acta Neuropathologica Communications SP - 75 VL - 1 IS - 1 AB - The Blood–brain barrier (BBB) controls brain supply with oxygen and nutrients, and protects the brain from toxic metabolites, such as beta-amyloid (Aβ) peptides. The neurovascular unit (NVU) couples vascular and neuronal functions by controlling BBB parameters based on brain needs. As such, NVU/BBB dysfunction, associated to irregularities in cerebral blood flow (CBF), has been proposed to contribute in the pathogenesis of Alzheimer’s disease (AD), mainly by impairing cerebral Aβ clearance. However, the spatiotemporal contribution of the NVU/BBB in the neurodegenerative cascades remains elusive. SN - 2051-5960 UR - https://doi.org/10.1186/2051-5960-1-75 DO - 10.1186/2051-5960-1-75 ID - ElAli2013 ER -